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COVID-19 Update: 08MAY2020

Colorado has issued a statewide safer-at-home health order, whereby Pyxant Labs will remain open as a critical healthcare operation. In accordance with the CDC's Interim Guidance for Businesses and Employers, Pyxant Labs is monitoring the spread of COVID-19, while providing continued service during this global emergency. We are committed to supporting our clients' efforts to combat COVID-19 and help restore health around the world.
  • Pyxant Labs is a high-end customer-centric bioanalytical contract research organization. At any stage in your program, our commitment is to provide you with quick, accurate results. We are confident your data will withstand any regulatory scrutiny and help you make those crucial program decisions.
  • Pyxant Labs is a high-end customer-centric bioanalytical contract research organization. At any stage in your program, our commitment is to provide you with quick, accurate results. We are confident your data will withstand any regulatory scrutiny and help you make those crucial program decisions.
  • Pyxant Labs is a high-end customer-centric bioanalytical contract research organization. At any stage in your program, our commitment is to provide you with quick, accurate results. We are confident your data will withstand any regulatory scrutiny and help you make those crucial program decisions.
  • Pyxant Labs is a high-end customer-centric bioanalytical contract research organization. At any stage in your program, our commitment is to provide you with quick, accurate results. We are confident your data will withstand any regulatory scrutiny and help you make those crucial program decisions.
  • Pyxant Labs is a high-end customer-centric bioanalytical contract research organization. At any stage in your program, our commitment is to provide you with quick, accurate results. We are confident your data will withstand any regulatory scrutiny and help you make those crucial program decisions.
  • Pyxant Labs is a high-end customer-centric bioanalytical contract research organization. At any stage in your program, our commitment is to provide you with quick, accurate results. We are confident your data will withstand any regulatory scrutiny and help you make those crucial program decisions.

Services

Pyxant Labs is a bioanalytical contract research organization (CRO) that offers analytical research, development, and validation services to support early stage drug discovery, pre-clinical studies, and clinical trial sample analysis. Our capabilities include assays for small-molecules, antisense oligonucleotides, RNA therapeutics, gene therapy programs, and peptides in an extraordinarily wide variety of challenging biological matrices, such as plasma and different solid and liquid tissues including umbilical cord, gut slurry, and ocular tissues. We also assay custom biomarkers to both GLP and CLIA requirements.

We operate at a scale which enables a full range of mass spectrometry services alongside value-added personal service. Our customers appreciate the combination of leading science, fast response, and regulatory leadership for their bioanalytical development requirements.
 
 

Fast Turnaround Discovery

Our specialized discovery team has the ability to issue data within 24 hours from the time of sample receipt. With our in-life partners, we are consistently able to provide an end-to-end service from dosing to data.

Method Development & Validation

Our highly skilled and experienced scientists develop and validate customized methods within a diverse range of compound classes, as well as unique biological matrices, following guidance of various regulatory agencies including FDA (CDER, CVM), EMA, and Health Canada.

Sample Analysis

We conduct expert bioanalysis from discovery through clinical phase studies in varying compound classes, such as small molecules, RNA therapeutics (oligonucleotides), peptides, and anti-body drug conjugates (ADCs), in all biological matrices including plasma, urine, feces, and an extensive number of tissues.

FDA Center for Veterinary Medicine Support

Pyxant Labs Inc. has been actively supporting CVM registrations since 2006. Our scientists have industry‑leading expertise in method validation and sample analysis to support abbreviated new animal drug applications (ANADA) bioequivalence studies. Pyxant Labs Inc. has worked with over a dozen different animal health companies within the United States and Europe and has performed bioanalytical analysis on multiple ANADA approvals.

Pyxant Labs Inc. supports CVM clients from early development pilot studies to pivotal bioequivalence studies. Our scientists develop fit-for-use assays which can be used to quickly and accurately evaluate generic formulations against innovator drugs to determine if the drug product shows promise. Once pilot studies are complete, our bioanalytical assays move into method validation, and a complete regulatory package is submitted to the client for CVM review prior to conducting the pivotal bioequivalence study.

High-Resolution Mass Spectrometry

Pyxant Labs has expanded into high-resolution mass spectrometry (HRMS) with the recent acquisition of a Thermo Q Exactive Plus and its industry-leading high-resolution accurate mass (HRAM) capabilities.

Oligonucleotide Testing

In addition to our years of experience with LC/MS/MS, Pyxant Labs offers support for oligonucleotide testing using high-resolution mass spectrometry (HRMS), hybridization-based LC-fluorescence, hybridization ELISA, or branched DNA techniques, which we are implementing at Pyxant Labs.

Tissue Bioanalysis

Pyxant Labs offers unmatched scientific expertise in developing assays for an extensive number of unique tissues, including brain, lung, kidney, cornea, optic nerve, umbilical cord, spinal cord, and more, to provide data pertaining to target identification and biodistribution related DMPK and ADME projects. By developing specialized homogenization, stabilization, and extraction procedures, Pyxant Labs can accommodate a wide variety of our clients’ tissue bioanalysis needs. Developing and validating custom tissue assays is routine for our scientists, and our capabilities can serve a range of regulatory requirements, including FDA, EMA, CVM, VICH, and more. With the efficiency and execution of tissue bioanalysis performed at Pyxant Labs, you will be able to appropriately strategize the next steps in your drug development process from discovery through clinical work.

Non-Proprietary Assays

Please, contact us if your compound is not on this list.
 


Tables below scroll left or right.

Bioanalytical Method Matrix Method Range Sample Volume
Acyclovir aka Aciclovir Skin (Franz Cell
Receptor Fluid)
1 to 1,000 ng/mL 50 µL
Acepromazine aka Acetylpromazine Canine Plasma 1 to 1,000 ng/mL 25 µL
Acetaminophen Human Plasma 250 to 10,000 ng/mL 25 µL
Atazanavir Human Plasma 10 to 10,000 ng/mL 50 µL
Atomoxetine Human Plasma 1 to 1,000 ng/mL 50 µL
ATRIPLA™ (Tenofovir, Emtricitabine, Efavirenz) Human Plasma 5 to 5,000 ng/mL 50 µL
Azithromycin Feline Plasma 100 to 100,000 ng/mL 50 µL
Broflanilide Bovine Plasma/Tissue 0.5 to 500 ng/mL 100 µL
Budesonide Human Plasma 10 to 750 pg/mL 150 µL
Buprenorphine Rabbit/Rat/Mouse Plasma 0.5 to 100 ng/mL 50 µL
Capsaicin Human Plasma 0.05 to 50 ng/mL 100 µL
Captisol® Human Plasma 2 to 200 µg/mL 50 µL
Carprofen Canine Plasma 100 to 75,000 ng/mL 50 µL
Clarithromycin Feline Plasma 1 to 1,000 ng/mL 25 µL
Clomipramine Canine Plasma 0.5 to 250 ng/mL 50 µL
Darunavir Human Plasma 10 to 10,000 ng/mL 50 µL
Deracoxib Canine Plasma 10 to 5,000 ng/mL 50 µL
Deracoxib Tramadol, Concurrent Assay Canine Plasma 10 to 5,000 ng/mL
10 to 1,000 ng/mL
50 µL
Detomidine Equine Plasma 1 to 1,000 ng/mL 25 µL
Dextromethorphan Human Plasma 1 to 500 ng/mL 50 µL
Dextromethorphan Human Urine 1 to 500 ng/mL 50 µL
Dextrorphan Human Plasma 1 to 500 ng/mL 50 µL
Dextrorphan Human Urine 1 to 500 ng/mL 50 µL
Diclofenac Beagle Plasma 1 to 1,000 ng/mL 150 µL
Digoxin Human Plasma 100 to 50,000 ng/mL 50 µL
Drontal Plus: Praziquantel and Pyrantel Pamoate Beagle Plasma 0.5 to 1,000 ng/mL 50 µL
Enrofloxacin Canine/Feline Plasma 2 to 2,000 ng/mL 50 µL
Fenbendazole Equine Plasma 1 to 1,000 ng/mL 50 µL
Floxuridine (Free and Total) Monkey Plasma 5 to 1,000 ng/mL 25 µL
Flunixin Equine Plasma 1 to 1,000 ng/mL 25 µL
Fluoxetine Human Plasma 0.1 to 50 ng/mL 150 µL
Gemfibrozil Human Plasma 50 to 50,000 ng/mL 25 µL
Granisetron Beagle/Pig Plasma 0.05 to 50 ng/mL 100 µL
Bioanalytical Method Matrix Method Range Sample Volume
Hydrochlorothiazide aka HCTZ, HCT, HCZ Human Plasma 1 to 250 ng/mL 300 µL
Hyrocodone Human Plasma 0.75 to 50 ng/mL 100 µL
Indomethacin aka Indometacin Beagle Plasma 1 to 1,000 ng/mL 150 µL
Ketoconazole Human Plasma 20 to 10,000 ng/mL 50 µL
Latanoprost and latanoprost Free Acid Human/Minipig/Rabbit Plasma 50 to 1,500 pg/mL 250 µL
Lisdexamphetamine d-Amphetamine Human Plasma 0.25 to 100 ng/mL
1 to 100 ng/mL
50 µL
Methotrexate aka Amethopterin Human Plasma 1 to 200 ng/mL 200 µL
Methamizole Feline Plasma 2 to 2,000 ng/mL 50 µL
Methylphenidate Human Plasma 0.05 to 25 ng/mL 100 µL
Metoprolol Human Plasmaa 0.25 to 250 ng/mL 100 µL
Midazolam and α-Hydroxymidazolam Human Plasma 0.1 to 100 ng/mL 100 µL
Milbemycin Oxime Canine/Feline Plasma 10 to 2,000 ng/mL 50 µL
Montelukast and Montelukast 1,2-diol Human Plasma 5 to 1,000 ng/mL 50 µL
Moxidectin Human Plasma 0.5 to 100 ng/mL 100 µL
Nitroglycerin, 1,2 Dinitroglycerin, 1,3 Dinitroglycerin Human Plasma 20 to 8,000 ng/mL 250 µL
Norfluoxetine aka Seproxetine Human Plasma 0.1 to 50 ng/mL 150 µL
Olanzapine Beagle Plasma 0.1 to 50 ng/mL 100 µL
Omeprazole Equine Plasma 1 to 1,000 ng/mL 25 µL
Phenylbutazone Equine Plasma 25 to 5,000 ng/mL 200 µL
Phenylpropanolamine Canine Plasma 1 to 1,000 ng/mL 25 µL
Raltegravir Human Plasma 10 to 10,000 ng/mL 50 µL
Rosiglitazone Minipig/Human Plasma 50 to 5,000 ng/mL 75 µL
Roxithromycin Feline Plasma 100 to 50,000 ng/mL 25 µL
Scopolamine Human Plasma 0.002 to 2 ng/mL 300 µL
Sildenafil and N-desmethyl Sildenafil Human Plasma 0.5 to 500 ng/mL 50 µL
Sofosbuvir and GS331007 Human Plasma 2 to 2,000 ng/mL 50 µL
Sulfadiazine Trimethoprim Equine Plasma 100 to 10,000 ng/mL
10 to 1000 ng/mL
50 µL
Tapentadol Human Plasma 0.2 to 200 ng/mL 50 µL
Telmisartan Human Plasma 0.5 to 5,000 ng/mL 25 µL
Tivozanib Rabbit Plasma/Tissue 0.1 to 50 ng/mL 50 µL
Topiramate Human Plasma 5 to 750 ng/mL 50 µL
Triamcinolone Acetate Human Plasma 1 to 500 ng/mL 200 µL
Valdecoxib Human Plasma 0 to 300 ng/mL 500 µL

Quality & Compliance


Quality Assurance & Reporting

Our in-house Quality Assurance department oversees the integrity of all the data we generate and the reports we publish. Pyxant Labs' QA team is set up to simulate an on-site FDA audit team, ensuring we adhere to the latest guidance. GLP studies are run against a set of standard operating procedures by staff who have received extensive training on all aspects of the study.

Additionally, our Quality Assurance Manager is a member of the GLP section and a co-chair of the Bioanalytical Specialty section for the Society of Quality Assurance and is a member of the Rocky Mountain Regional Chapter of the Society of Quality Assurance. Moreover, our Laboratory Direct has been a member of the Global CRO Council (GCC) since its inception.

Besides regular internal audits, Pyxant Labs always welcomes audits and site inspections from existing and potential clients. We have had multiple inspections to date by the FDA (CDER, CVM), which resulted in no findings impacting data quality.

We have a dedicated technical team assigned to reporting and offering customized reports on a project-by-project basis.

Customer Service Team

 
You will often find our customer service team members at conferences or at meetings, exchanging knowledge and networking with those in the industry. If you happen to be at the same event, feel free to reach out to us for a meeting, or stop by our table if we’re exhibiting.
Customer Service Team

Adam Winstrom

Director, Client Management

Michael Olson

Director of Business Development

Pam Stevenson

Director of Business Development

Olivia Franks

Client Manager

Kathryn Sears

Senior Program Manager

Jeremy Thompson

Senior Program Manager

Cassidy Hatch

Study Coordinator

Kylie Smith

Study Coordinator

Careers

Pyxant Labs is a dynamic company encompassing a growing bioanalytical contract research organization and a high-end reference laboratory subsidiary. Our core focus is on customer service, as well as regulatory and technical expertise, structured to create industry leading customer satisfaction.

We recognize experienced and highly qualified team players are essential to the success of our company. The only way to deliver on our objectives is to recruit, develop, and retain exceptional people. Our human resources management practices, including training, role design, project assignments, and infrastructure, contribute to a successful employee experience.

Current Positions

Pyxant CRO analyzing vials

Contact Us

We are located in Colorado Springs, CO conveniently close to downtown and I-25.

From I-25, head west on Garden of the Gods Road, turn right on Forge Road, then turn left at 4720 Forge Road, Suite 106, Colorado Springs, CO 80907.

Our staff is always available for questions. Call us during business hours, or e-mail us anytime.

Phone: +1 (719) 593-1165
Fax: +1 (719) 593-1625
E-mail: info@pyxant.com