LC/MSMS
Applied Biosystems MDS Sciex API 4000 and 3000s. Large installed
base for bioanalytical APCI, ESI and photo ionization CTC
Analytics HTS PAL Autosampler Supporting high throughput analysis
with very low carry-over.
GC/MS
ThermoFinnigan Trace DSQEI and CI (+ and -)200 L/s split flow
pumps, supporting PPINICI10,000 amu/sec scan speed Fast change
ion sources Simultaneous SIM and full scan capability Mass
range 1 to 1050 amu Curved pre-filter.
In
addition to our mass spec platform, our laboratory is equipped
with the following instrumental configurations:
Gas
chromatographs: HP 5890 and Shimadzu GC-2010
Detectors for GC: Flame ionization detector (FID),
nitrogen phosphorous detector (NPD), electron capture detector
(ECD), flame photometric detector (FPD), thermal conductivity
detector (TCD).
Liquid
chromatographs: HP models 1090 and 1100
Detectors for HPLC: Filtered photometric, photodiode
array, fluorescence ELCD.
Also,
our laboratory has extensive capabilities in the following
conventional techniques:
Extractions: Extensive expertise in the efficacy
of particular solvents targeting specific test substances
in a wide range of biological matrices…extraction options
include reflux capabilities, Soxhlet extractions, Turbovaps,
and various mechanical maceration techniques.
Sample cleanup: Extensive expertise in selecting
sample cleanup approaches that eliminate interferences from
the matrix, facilitating very low limits of quantitation…sample
cleanup options include column chromatography with a variety
of sorbents, SPE cleanup, GPC cleanup, and cation exchange
chromatography.
Sample
preparation: Comprehensive experience in processing
biological matrices including whole blood, plasma, animal
tissues, vegetables, fruits, grains, air, water, soil, milk,
stomach contents, and urine.
Storage stability: Two Forma Scientific
Model 3940 environmental chambers (temperature and relative
humidity control); refrigerators, freezers, and ambient conditions
with temperature monitoring.
Chemistry-intensive methods: Significant experience
with hydrolysis, distillations, and derivatization methods.
Other
technical capabilities include records archiving, reports
preparation, and 3,500 cubic feet of onsite GLP freezer and
refrigerator storage for samples.
